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    Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents

  • In This Issue
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 18, 2025 - 8:00 am
  • Quantification of redox thermodynamics shifts within coacervates
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceThe earliest enzymes are thought to have formed through the assembly of macromolecules into disordered, secondary phases known as coacervates. While these phases are believed to have played a role in early catalysis, the underlying mechanisms ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Digital tools for analyzing nondiffeomorphic shapes
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceA key limitation to using geometric morphometrics is the lack of high-fidelity tools. The most powerful methods in geometric morphometrics require that the meshes are similar, but not all geometric data satisfy this requirement. The Euler ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • The Kinship Formula: Inferring the numbers of all kin from any structured population projection model
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceWe derive the Kinship Formula which yields the number of any kin from any structured population projection model. This formula should prove important across fields utilizing structured population dynamics. For example, it can assist ecologists ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>Mutations in Argonaute proteins (AGOs) cause Argonaute syndrome, a neurodevelopmental disorder (NDD), yet the underlying molecular mechanism remains unclear. We determined cryo-electron microscopy (cryo-EM) structures of wild-type (WT) AGO1 and the ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Advancing stochastic 3-SAT solvers by dissipating oversatisfied constraints
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceHard decision problems, in computational complexity theory known as NP-complete, are of universal importance. From a conceptual perspective, an efficient solution to one such complete problem is tantamount to solving any other in the wide ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceAutophagosomal components recycling (ACR) is a recently discovered recycling process responsible for the recycling of autophagosome outer membrane components from autolysosomes. The optimal function of this process is imperative for proper ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am

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SciTechDaily

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    SciTechDaily

  • The “Impossible” LED: Cambridge Team Successfully Powers Insulating Nanoparticles
    Scientists have discovered how to electrically power insulating nanoparticles using molecular antennas, creating exceptionally pure near-infrared LEDs with wide-ranging potential. A newly developed approach uses “molecular antennas” to direct electrical energy into nanoparticles that normally cannot conduct electricity. This advance has led to a completely new category of ultra-pure near-infrared... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 10:51 pm
  • Astronomers Solve 70-Year-Old Cosmic Ray Mystery
    Chinese researchers have identified black holes as the likely source of the high-energy component of the cosmic-ray “knee.” Milestone findings released on November 16 by the Large High Altitude Air Shower Observatory (LHAASO) have provided a major breakthrough in explaining a long-standing puzzle in cosmic ray research. Scientists have spent... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 10:16 pm
  • World Record Broken: 50-Qubit Quantum Computer Fully Simulated for the First Time
    The JUPITER supercomputer set a new milestone by simulating 50 qubits. New memory and compression innovations made this breakthrough possible. A team from the Jülich Supercomputing Centre, working with NVIDIA specialists, has achieved a major milestone in quantum research. For the first time, they successfully simulated a universal quantum computer... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 9:41 pm
  • Scientists Teleport Information Between Distant Photons for the First Time
    Researchers at the University of Stuttgart have successfully teleported quantum states between photons from two distant light sources, marking a pivotal advance toward practical quantum repeaters. Life online remains vulnerable, with cybercriminals able to access financial accounts or impersonate individuals with increasing ease. The rise of AI has enabled attackers... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 9:06 pm
  • Why Eating Alone Could Be Surprisingly Dangerous for Older Adults
    A major review reveals that mealtime companionship may play a surprisingly important role in the nutrition and health of older adults. Older adults who often eat by themselves may face a higher likelihood of poor nutrition and related health issues compared with those who regularly share meals, according to new... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 5:03 pm
  • Scientists Say Time Matters As Much as Diet and Exercise for Your Brain
    Time may be a key missing factor in dementia prevention, according to new research from UNSW Sydney’s Centre for Healthy Brain Aging (CHeBA). New research suggests that time – or the lack of it – may be the missing link in effective dementia prevention. The research, published in The Lancet... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 4:28 pm
  • Watching Less TV Could Cut Depression Risk by up to 43%, Study Finds
    A large cohort study found that swapping TV-watching for physical activity can meaningfully lower the risk of depression, particularly in middle-aged adults. A study published in European Psychiatry reports that replacing time spent watching TV with other daily activities may help lower the risk of depressive disorder for middle-aged adults.... Read more »
    Source: SciTechDaily | Published: November 22, 2025 - 3:52 pm

JOHNS HOPKINS UNIVERSITY

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NEUROSCIENCE NEWS

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    Neuroscience News

  • What Triggers Tantrums? Sensory Overload May Be To Blame
    New research reveals a distinct brain activity signature in children who become overwhelmed by sensory input such as noise, touch, or bright lights. Using functional MRI, scientists found that overly sensitive children show reduced activation in outward-facing sensory and motor networks while increasing activation in inward-focused networks tied to cognition... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 9:53 pm
  • Brain Circuit That Forces Behavior Into “Repeat Mode” Identified
    A new study has identified a specific brain circuit that can push behavior into a compulsive “repeat mode,” forcing mice to continue digging and sniffing even when rewards are available. The circuit links the nucleus accumbens to the hypothalamus and then to the lateral habenula, a region involved in processing... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 8:59 pm
  • Genetics Plus Heart Health Markers Sharpen Dementia Risk
    New research shows that dementia risk is best predicted by combining genetic vulnerability with cardiovascular disease markers, revealing a more precise and actionable way to identify who is most likely to develop the condition. While genes such as APOE4 and family history contribute heavily, equally powerful are modifiable factors like... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 7:55 pm
  • Supplement Shows Promise in Blocking Amyloid in Alzheimer’s
    A new study shows that oral arginine, a naturally occurring amino acid, can significantly suppress amyloid-β aggregation in Alzheimer’s disease models. Researchers found that arginine not only prevented Aβ42 from clumping but also reduced plaques and inflammation in mouse and fruit fly models carrying Alzheimer’s-related mutations.... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 7:03 pm
  • Early Brain Activity Differences Predict Addiction Risk in Boys vs Girls
    A large-scale analysis of nearly 1,900 children found that those with a family history of substance use disorder show early differences in how their brains transition between activity states, long before any drug exposure. Girls with family history showed increased transition energy in introspective networks, suggesting greater difficulty shifting out... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 6:37 pm
  • Screen Time in Tweens Predicts ADHD, Slower Brain Growth
    A large, two-year study of nearly 12,000 children found that higher screen time at ages 9–10 predicts an increase in ADHD symptoms, independent of a child’s starting symptom level. Brain imaging revealed that heavy screen use is associated with smaller cortical volume and disrupted development in regions critical for attention,... Read more »
    Source: Neuroscience News | Published: November 21, 2025 - 5:13 pm
  • Thrill Fatigue: How Dopamine Devalues Repeated Rewards
    New research shows that the same dopamine receptor mechanism responsible for drug addiction also governs the natural decline in motivation when we repeat rewarding behaviors. By studying male fruit flies, researchers found that dopamine acting through the D2 receptor promotes persistence during mating, but repeated experiences cause these receptors to... Read more »
    Source: Neuroscience News | Published: November 20, 2025 - 10:18 pm

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