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    Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents

  • In This Issue
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 18, 2025 - 8:00 am
  • Quantification of redox thermodynamics shifts within coacervates
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceThe earliest enzymes are thought to have formed through the assembly of macromolecules into disordered, secondary phases known as coacervates. While these phases are believed to have played a role in early catalysis, the underlying mechanisms ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Digital tools for analyzing nondiffeomorphic shapes
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceA key limitation to using geometric morphometrics is the lack of high-fidelity tools. The most powerful methods in geometric morphometrics require that the meshes are similar, but not all geometric data satisfy this requirement. The Euler ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • The Kinship Formula: Inferring the numbers of all kin from any structured population projection model
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceWe derive the Kinship Formula which yields the number of any kin from any structured population projection model. This formula should prove important across fields utilizing structured population dynamics. For example, it can assist ecologists ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>Mutations in Argonaute proteins (AGOs) cause Argonaute syndrome, a neurodevelopmental disorder (NDD), yet the underlying molecular mechanism remains unclear. We determined cryo-electron microscopy (cryo-EM) structures of wild-type (WT) AGO1 and the ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • Advancing stochastic 3-SAT solvers by dissipating oversatisfied constraints
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceHard decision problems, in computational complexity theory known as NP-complete, are of universal importance. From a conceptual perspective, an efficient solution to one such complete problem is tantamount to solving any other in the wide ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am
  • mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation
    Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceAutophagosomal components recycling (ACR) is a recently discovered recycling process responsible for the recycling of autophagosome outer membrane components from autolysosomes. The optimal function of this process is imperative for proper ...... Read more »
    Source: Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents | Published: November 14, 2025 - 8:00 am

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SciTechDaily

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    SciTechDaily

  • ● AI Blood Cell Analyzer Outperforms Human Experts in Detecting Leukemia
    A new AI system called CytoDiffusion could reshape how blood disorders such as leukemia are detected by analyzing blood cell morphology with remarkable sensitivity and awareness of its own uncertainty. An AI system capable of examining the shape and structure of blood cells with higher accuracy and consistency than human... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 6:10 pm
  • ● Deep Brain Recordings Reveal How Mounjaro Suppresses Food Cravings
    A Penn case study finds that a brain-computer interface shows the medication produces only short-term or incomplete effects on related brain activity in a patient with obesity, highlighting the need for further research. A rare look at the brain activity of a patient with obesity and loss of control eating... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 5:35 pm
  • ● A Common Nutrient Deficiency May Be Triggering Early Brain Damage in Young Adults
    Obesity in young adults appears to trigger early biological changes linked to inflammation, liver stress, and neuronal damage. Researchers found that low choline levels strongly correlate with these risks, hinting at a nutrient gap affecting long-term brain health. How Physical Health Shapes Brain Health Researchers have long recognized that problems... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 5:00 pm
  • ● Your Brain Quietly Rewrites Reality Depending on Your State of Mind
    Researchers found that the prefrontal cortex customizes its signals to the brain’s visual and motor systems, shaping perception based on arousal and movement. Two key regions balance each other to sharpen or suppress visual information as needed. How Brain State and Behavior Shape What Mice See Vision guides how animals... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 4:00 pm
  • ● Hidden Thyroid Problem in Pregnancy Linked to Autism
    Researchers found that mothers with untreated or persistent thyroid hormone imbalance across pregnancy face a higher chance of having children diagnosed with autism. The study also revealed that longer periods of imbalance led to higher autism rates in offspring. The results emphasize the importance of frequent thyroid monitoring. Thyroid Imbalance... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 2:00 pm
  • ● Scientists Unveil Breakthrough Low-Temperature Fuel Cell That Could Revolutionize Hydrogen Power
    Researchers at Kyushu University have created a solid oxide fuel cell (SOFC) exhibiting exceptionally high proton conductivity at 300°C. As worldwide energy needs continue to rise, scientists, industry leaders, and policymakers are collaborating to find reliable ways to meet growing demand. This effort has become increasingly urgent as nations work... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 12:39 pm
  • ● “We Have Never Seen This Before” – New Crystal Superconductor Is the Strangest of Its Kind
    A new study reveals that PtBi2, an otherwise ordinary-looking crystal, hosts an entirely new form of superconductivity confined to its top and bottom surfaces. Something unusual is happening inside the compound platinum-bismuth-two (PtBi2). A new investigation by scientists at IFW Dresden and the Cluster of Excellence ct.qmat shows that although... Read more »
    Source: SciTechDaily | Published: November 25, 2025 - 12:04 pm

JOHNS HOPKINS UNIVERSITY

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NEUROSCIENCE NEWS

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    Neuroscience News

  • ● Untreated Sleep Apnea Doubles Parkinson’s Risk
    A large analysis of more than 11 million medical records found that people with untreated obstructive sleep apnea face a substantially higher risk of developing Parkinson’s disease over time. Even after accounting for factors like age, obesity, and cardiovascular conditions, those who did not use CPAP were nearly twice as... Read more »
    Source: Neuroscience News | Published: November 25, 2025 - 1:58 pm
  • ● Genes Behind Dog Behaviors Also Shape Human Emotions
    Researchers analyzed the genomes and behavioral profiles of 1,300 golden retrievers and found that several behavioral traits—such as trainability, fear of strangers, and aggression toward other dogs—are shaped by specific genetic variants. Remarkably, a dozen of these same genes also influence emotional and cognitive traits in humans, revealing shared biological... Read more »
    Source: Neuroscience News | Published: November 25, 2025 - 1:30 pm
  • ● Gene Discovery Reveals Hidden Risk Pathway for Delirium
    A massive genetic analysis of over one million people has revealed that APOE, long known for its role in Alzheimer’s disease, also independently increases a person’s risk of delirium. The researchers found that this effect cannot be explained solely by dementia, showing that APOE directly contributes to delirium vulnerability in... Read more »
    Source: Neuroscience News | Published: November 25, 2025 - 12:59 pm
  • Thought Begins Before We’re Born
    New research using human brain organoids shows that early neural activity follows structured, time-based patterns long before sensory experience begins. These findings suggest the human brain comes preconfigured with a built-in “operating system” for organizing information, rather than relying solely on external input to form its circuits.... Read more »
    Source: Neuroscience News | Published: November 24, 2025 - 9:41 pm
  • Genetics Point to a New Type of Suicide Risk
    New research shows that many people who die by suicide without prior suicidal thoughts or behaviors are not simply “missed cases”—they may have an entirely different underlying risk profile. Genetic analyses of more than 2,700 deaths revealed that these individuals carry fewer genetic risk factors for major psychiatric conditions compared... Read more »
    Source: Neuroscience News | Published: November 24, 2025 - 8:19 pm
  • Stress-Like Behaviors Traced to a Single ATP Circuit in the Brain
    New research reveals that reduced ATP signaling in the hippocampus plays a causal role in both depression- and anxiety-like behaviors. In stressed male mice, ATP levels and the ATP-releasing protein connexin 43 were markedly lower.... Read more »
    Source: Neuroscience News | Published: November 24, 2025 - 7:05 pm
  • Psychedelic ‘Ego Death’ Tied to a Collapse in Alpha Brain Waves
    A new study using DMT as a scientific tool reveals how psychedelics alter the brain’s alpha-wave dynamics and weaken our sense of self. The researchers found that DMT pushes the brain away from its usual “critical” balance between chaos and order, a state believed to be essential for coherent self-awareness... Read more »
    Source: Neuroscience News | Published: November 24, 2025 - 6:32 pm

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