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    Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents

  • In This Issue
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>... Read more »
  • Systemic collapse emergence from climate-induced perturbations in transportation networks
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificanceHuman-made infrastructures are vulnerable to external stressors (e.g., due to climate), and their interaction can generate perturbations affecting system functionality. Even localized perturbations can propagate to remote parts of the system ...... Read more »
  • Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificanceWhen it comes to the health of a pregnancy and the child, the mother has long been the focus. However, an accumulation of evidence from animal models indicates that a father’s health and exposures are equally important.... Read more »
  • PCS-UQ: Uncertainty quantification via the Predictability–Computability–Stability framework
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificanceTrustworthy uncertainty quantification is key for responsible data science and AI (including data-driven decision-making). Traditional statistical inference methods require specifying an underlying generative model and are often not robust to ...... Read more »
  • Nuclear BbAtg8 interacts with BbMac1 as a transcriptional modulator to sustain nuclear copper homeostasis during conidial germination
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificancePathogenic fungi must overcome host-imposed trace-metal starvation, known as nutritional immunity, to establish successful infections. This study uncovers a remarkable dual-track survival mechanism inBeauveria bassianathat strictly ...... Read more »
  • Controlled functionalization of cellulose nanocrystals directs polymer-specific protein coronas and immune cell interactions
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificanceFunctional nanomaterials can contain hydrophobic imaging or therapeutic groups that increase nonspecific protein adsorption. Although antifouling polymers are used to reduce these effects, their influence extends beyond suppressing protein ...... Read more »
  • Thermal imbalance drives avian performance and responses to climate warming
    Proceedings of the National Academy of Sciences, Volume 123, Issue 42, October 2026. <br/>SignificanceClimate change is reshaping species’ performance, reproduction, and geographic distributions, yet predicting these responses is challenging for many organisms. For ectotherms, performance can often be predicted from environmental temperature, ...... Read more »

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UNIVERSITY OF MICHIGAN

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UNIVERSITY OF SOUTHAMPTON

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SciTechDaily

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    SciTechDaily

  • A Bizarre 170-Million-Year-Old Predator Is Rewriting What We Know About Ancient Crocodiles
    A Moroccan crocodile relative’s teeth resemble those of prehistoric filter feeders, suggesting that different reptile groups independently evolved similar tools for catching tiny aquatic prey. A crocodile relative that lived around 170 million years ago had a long, narrow snout lined with exceptionally thin, needle-like teeth. No known close relative... Read more »
  • Medieval Children Were Exposed to Shocking Levels of Lead, 1,000 Years Before the Industrial Revolution
    Children in medieval English mining communities faced lead exposure matching or exceeding that in Industrial Revolution cities, with social standing apparently shaping who bore the greatest burden. Between the 16th and 19th centuries, lead producers in the Derbyshire Peak District of central England repeatedly remelted waste left by Roman and... Read more »
  • Eating 30% Less Food Has an Unexpected Effect on DNA, Study Finds
    A study reveals that calorie restriction affects genetic mutations differently across tissues and regions of DNA. Eating fewer calories may do more than slow certain aspects of aging. Scientists have found that mice consuming 30 percent less food accumulated fewer DNA mutations across several tissues, suggesting that diet can influence... Read more »
  • Tiny Atomic Defects Reveal a Quantum Secret Hidden Inside an Unusual Metal
    Atomic-scale defects in an unusual metal may offer a new way to control quantum states. Scientists at Columbia University have discovered that electron waves can become trapped inside a metal, even when pathways remain available for them to escape. The finding, published in Science, provides the first experimental evidence of... Read more »
  • Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside
    Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide,... Read more »
  • A Single Enzyme Could Hold the Key to Treating a Devastating Brain Disorder
    Blocking an enzyme’s production restored brain growth and healthy behaviors in mice engineered to develop Angelman syndrome, pointing to a possible treatment target. Children with Angelman syndrome begin to show difficulties with thinking and movement at around 6 months of age. The rare condition occurs in approximately one in 20,000... Read more »
  • Just Two Days on a Vegan Diet Triggered Unexpected Changes in the Liver
    Switching from a vegetarian to a vegan diet altered liver metabolism in mice within just two days, making glucose production and toxic waste removal less efficient. Millions of people follow a vegan diet, excluding all animal-derived products. Plant-based eating is recommended in part for its environmental benefits, but the health... Read more »

JOHNS HOPKINS UNIVERSITY

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NEUROSCIENCE NEWS

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    Neuroscience News

  • Psilocybin Replaces Lost Synapses in Depressed Brains
    Does healing the brain with psychedelics require a "trip"? A new study shows psilocybin drives synaptic plasticity through Layer 5 pyramidal neurons independently of hallucinogenic signaling, opening the door to non-hallucinogenic depression therapeutics.... Read more »
  • Neural Chip Powers Adaptive DBS for Depression
    Treating psychiatric illnesses with deep brain stimulation requires tracking multi-region brain networks. EPFL researchers developed LogSync, an ultra-low-power system-on-chip operating under 200 microwatts that decodes oscillatory synchrony to deliver real-time, responsive neuromodulation.... Read more »
  • Genetic Blueprint of Personality Revealed
    There is no single gene for being outgoing or anxious. A landmark Nature study of more than one million people identifies 1,260 genetic variants shaping the Big Five personality traits, showing that thousands of tiny DNA differences combine with environmental life experiences to mold human character.... Read more »
  • Ultra-Processed Foods Sensitize Children’s Brain Reward Circuits
    Ultra-processed foods may condition developing brains to overeat. A longitudinal fMRI study in JAMA Network Open shows that high UPF intake sensitizes children's dorsal striatum to appetizing food images, directly driving body fat and BMI increases one year later.... Read more »
  • How the Brain Maps Every Number
    How does the human brain process abstract mathematical values? Brain scans from the INSERM-CEA Cognitive Neuroimaging Unit reveal a continuous spatial map in the intraparietal sulcus that plots fractions and whole integers along a single mental number line.... Read more »
  • Non-Drug Breakthrough for Postpartum Depression
    A free, self-paced online program developed by CU Boulder and Mass General researchers reduces postpartum depression relapse by 26%. The nationwide trial of 500 expectant mothers in Lancet Public Health provides a proven digital alternative to medication for preventing maternal mental health crises.... Read more »
  • Cancer Drug Halts Fragile Brain Bleeds
    Cerebral Cavernous Malformation causes fragile, bleeding vascular lesions in the brain with no non-surgical treatment options. Researchers discovered that dabrafenib, an approved childhood cancer drug, suppresses vessel leakage and shrinks lesions in preclinical models.... Read more »

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